IBM support notes that SmartSuite will not operate on 64-bit Vista.
There are no plans to implement official support for SmartSuite on Vista, but no major problems have been reported to the Lotus support at this time:
On platforms other than XP (i.e. Server 2003, Longhorn, Vista), the client/server runtime environment that renders the Windows GUI can get bogged down when drawing poorly designed forms. Generally, these apparent "Vista bugs" can be fixed by redesigning the form so that fields are not crammed together. DSV is familiar with this "bug".